Neurobiologiste au Neurocentre Magendie, Inserm, Université de Bordeaux

Maître de conférence à l'Université de Bordeaux, neurobiologiste au Neurocentre Magendie (INSERM U862), spécialiste de la mémoire associée au stress (mémoire de peur normale et traumatique) dans ses aspects psychologiques, cognitifs et neurobiologiques.

Sélection de publications (*in refereed journals):

-*Desmedt A., Garcia R. & Jaffard R. (1998) Differential modulation of changes in hippocampal-septal synaptic excitability by the amygdala as a function of either elemental or contextual fear conditioning in mice. The Journal of Neuroscience, 18(1): 480-487.
-*Desmedt A., Garcia R. & Jaffard R. (1999) Vasopressin in the lateral septum promotes elemental conditioning to the detriment of contextual fear conditioning in mice. European Journal of Neuroscience, 11: 3913-3921.
-*Desmedt A. (1999) Du concept de “mémoire” à la notion d’ “expressions de souvenirs”. In Cognito, 15: 25-31.
-*Jaffard R., Etchamendy N., Desmedt A., Krazem A., Cortes-Torrea C. & Marighetto A. (2000) Modèle de la mémoire déclarative (relationnelle) humaine et de ses dysfonctionnements. Thérapie, 55: 477-485.
-Desmedt A. (2001) Perspectives en Neurosciences Cognitives: vers une nécessaire transdisciplinarité. Les Cahiers Alfred Binet (Ed. Erès), 667: 35-50.
-*Etchamendy N., Desmedt A., Cortes-Torrea C., Marighetto A. & Jaffard R. (2003) Hippocampal lesions and discrimination performance of mice in the radial maze: sparing or impairment depending on the representational demands of the task. Hippocampus, 13 : 197-211.
-*Desmedt A., Marighetto A., Garcia R. & Jaffard R. (2003) The effects of ibotenic hippocampal lesions on discriminative fear conditioning in mice: impairment or facilitation depending on the associative value of a phasic explicit cue. European Journal of Neuroscience, 17: 1953-1963.
-*Desmedt A., Hazvi S. & Dudai Y. (2003) Differential pattern of CREB activation in the rat brain after conditioned aversion as a function of the cognitive process engaged: taste vs. context association. The Journal of Neuroscience, 23(14): 6102-6110.
-*Desmedt A., Garcia R., Jaffard R. (2003) An 8-day extensive elemental, but not contextual, fear conditioning potentiates hippocampal-lateral septal synaptic efficacy in mice. Synapse, 49:270-278.
-*Yaniv D., Desmedt A., Jaffard R. & Richter-Levin G. (2004) The amygdala and appraisal processes: Stimulus and response complexity as an organizing factor. Brain Research Review, 44(2-3):179-86.
-*Revest J.M., Di Blasi F., Kitchener P., Rougé-Pont F., Desmedt A., Turiault M., Tronche F. & Piazza P.V. (2005) The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nature Neuroscience, 8(5):664-72.
-*Calandreau L, Desmedt A., Decortes L. & Jaffard R. (2005) A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning. Learning & Memory, 12: 383-388.
-*Trifilieff P., Herry C., Vanhoutte P., Caboche J., Desmedt A., Riedel G., Mons N., Micheau J. (2006) Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation. Learning & Memory, 13:349-358.
-*Calandreau L., Trifilieff P., Mons N., Costes L., Marien M., Marighetto A., Micheau J., Jaffard R., Desmedt A. (2006) Extracellular hippocampal acetylcholine level controls amygdala function and promotes adaptive conditioned emotional response. The Journal of Neuroscience, 26 :13556-13566.
-*Calandreau L., Jaffard R. & Desmedt A. (2007) Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning. Learning & Memory, 14: 422-429.
-*Marighetto A., Valerio S., Desmedt A., Philippin J.N., Trocme-Thibierge C. & Morain P. (2008) Comparative effects of the alpha7 nicotinic partial agonist, S24795 and the cholinesterase inhibitor, donepezil againstaging-related deficits in declarative and working memory in mice. Psychopharmacology, (Berl) 197:499-508.
-*Richard E., Helbling J.C., Tridon C., Desmedt A., Minni A.M., Cador A.,
Pourtau L., Konsman J.P., Mormède P. & Moisan M.P. (2010) Plasma transcortin influences endocrine and behavioural stress responses in mice. Endocrinology, 151(2):649-659.
-*Revest J.M., Kaouane N., Rougé-Pont F., Le Roux A., Vallée M., Turiault M., Tronche F., Desmedt A. & Piazza P.V. (2010) Enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib. Molecular psychiatry, 15(12):1125, 1140-51.
-*Calandreau L., Desgranges B., Jaffard R. & Desmedt A. (2010) Switching from contextual to tone fear conditioning and vice versa: The key role of the glutamatergic hippocampal-lateral septal neurotransmission. Learning & Memory, 17(9): 440-443.
-*Calandreau L., Bertin A., Boissy A., Arnould C., Constantin P., Desmedt A., Guémené D., Nowak R.,& Leterrier C. (2011) Effect of one week of stress on emotional reactivity and learning and memory performances in Japanese quail. Behavioural Brain Research, 217(1):104-10.
-*Kaouane N., Porte Y., Vallée M., Brayda-Bruno L., Mons N., Calandreau L., Marighetto A., Piazza P.V., Desmedt A. (2012) Glucocorticoids can induce PTSD-like memory impairments in mice. Science, 335(6075):1510-3.
-*Revest JM, Le Roux A, Roullot-Lacarrière V, Kaouane N, Vallée M, Kasanetz F , Rougé-Pont F, Tronche F, Desmedt A and Piazza PV (2014) BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Molecular Psychiatry, 19(9):1001-9.
-*Lucas M, Ilin Y, Anunu R, Kehat O, Xu L, Desmedt A and Richter-Levin G. (2014) Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat. Stress, 17(5):423-30.
-*Desmedt A, Marighetto A & Piazza PV (2015) Abnormal fear memory as a model for PTSD. Biological Psychiatry, Sep 1; 78(5): 290-7 (invited review).
-*Desmedt A, Marighetto A, Richter-Levin G & Calandreau L (2015) Adaptive emotional memory: The key hippocampal-amygdalar interaction. Stress, Aug 11:1-12 (invited review).

Experience

  • –present
    Neurobiologiste au Neurocentre de l'université Brodeaux 2, INSERM U862, Institut national de la santé et de la recherche médicale (Inserm)

Honours

-Prix: Laureate du prix scientifique de “La Recherche”, catégorie Médecine/Santé, 2013, pour la publication suivante: “Glucocorticoids can induce PTSD-like memory impairments in mice (2012) Science, 335(6075):1510-3”. -Prix: N. Kaouane et al., Science, 2012 as «Excellent paper in Neuroscience award » 2013 from ERA-NET NEURON.