Amy Rand

Our research centers on basic and applied questions related to contaminants in the environment. We use tools from environmental chemistry and toxicology to understand (1) where contaminants come from and where they go, (2) who gets exposed, and (3) the biological implications after exposure.

We explore routes of exposure to per- and polyfluoroalkyl substances (PFAS), a diverse class of over 8000 chemicals. PFAS have strong carbon-fluorine bonds that make them useful in many products, imparting grease- and water-resistance. But the same properties make some PFAS environmentally persistent and bioaccumulative.

Due to the structural diversity of PFAS, we use them as chemical probes to understand the underpinnings of biological transformation pathways. We elucidate enzymes and organisms responsible for transformation to explore biological mechanisms and conditions that may reduce the burden of PFAS contamination.

We also use biological models to study how exposure to one or more pollutants impacts signaling pathways involved in cell stress. Analytical chemistry and biochemical tools are coupled to gain insights into the mechanism of action of pollutants and their biological targets.

We are committed to doing environmental research with broad impact and for use in management decisions. To do so, we frequently collaborate with other academics, non-profit organizations, and government agencies.