Brendon joined the United States Studies Centre in 2009. He was previously with the Department of Politics and Public Policy at Griffith University.
Brendon was a visiting fellow at the Woodrow Wilson Centre in Washington DC in 2008 and 2015 and in 2006 he was a Fulbright Fellow at Georgetown University. He is the editor of seven books on anti-Americanism and has also published articles and books on American welfare policy, presidential politics, US foreign policy, and Australian-American relations. He has taught courses on American domestic politics and foreign affairs, and supervised theses on a variety of topics such as anti-Americanism, neoconservatism, the Iraq War and presidential politics. His two latest books are Anti-Americanism and American Exceptionalism: Prejudice and Pride about the USA and Ideologies of American Foreign Policy (co-authored with John Callaghan and Mark Phythian).