I joined Stellenbosch University in 1983 after a postdoc at the Roche Institute in New Jersey and established a high-quality cell culture facility in the department. The focus of the department changed to tuberculosis (TB) research in the 1990s and I was at the forefront of this change, investigating host-pathogen interactions in macrophages. This progressed to the question of genetic susceptibility, which has been my focus for the last 20 years. I have been the South African PI of a number of human genetic studies. I am currently the head of the group in the department working on host susceptibility to TB, consisting of approximately 20 people from BSc Hons students to senior researchers.