Jaime Colchero is group leader of the research group “Devices, Investigation and Applications in Nanoscience” (DIANA) at the Centre for Optics and Nanoscience of the Universidad de Murcia. He graduated in Physics at the University of Bonn, Germany (1988). His PhD-thesis was carried out at the ETH Zürich and University of Konstanz (1993). During this thesis, he firstly developed Scanning Force and Friction Microscopy and investigated the membrane protein Na,K-ATPase in liquid environment. After his PhD thesis, Dr. J. Colchero moved to the “Laboratorio de Nuevas Microscopías” at Universidad Autónoma de Madrid first as a postdoctoral researcher and later as lecturer and assistant professor. In 2001 he moved to the Universidad de Murcia as professor, where he founded the DIANA research group. The present lines of investigation of the Group DIANA are focused on several areas of Nanoscience, in particular the improvement of SFM based techniques and the application of AFM to fundamental processes at small scales.