The research of José González-Alonso revolves around two areas of human integrative cardiovascular physiology that have important implications for both athletic performance and exercise tolerance in health and disease. The first deals with cardiovascular responses to exercise using interventions such as heat stress, dehydration and large versus small muscle mass exercise to investigate how the human body copes with conditions that tax the cardiovascular system to its regulatory capacity. A second related area centres on the role of the erythrocytes and plasma adenosine triphosphate (ATP) on the control of the human circulation for which he uses a great variety of interventions in healthy and diseased individuals (i.e., hypoxia, anaemia, polycythaemia, hyperoxia, CO inhalation, intravascular nucleotide infusion, heat stress, dehydration, small versus large muscle mass exercise). His work has been published in high impact journals such as Journal of Physiology, Circulation, Circulation Research, American Journal of Physiology and Journal of Applied Physiology.