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Patrick Bertolino

Senior Research Fellow, Head of the Liver Immunology Group, Centenary Institute

Dr. Bertolino graduated from the University of Lyon in France and then trained as a post-doctoral fellow at the Walter and Eliza Hall Institute in Melbourne (1992-95). He then moved back to France at the ENS-Lyon (1995-97) before settling in Sydney at the Centenary Institute in 1997. Dr. Bertolino is internationally recognised as a world-leading expert in Liver Immunology. He has made major contributions related the ability of the liver to induce tolerance in transplantation, and chronic HCV infection. His group uses transgenic mouse models, advanced imaging technology and flow cytometry to understand how T cells interact and are instructed by liver cells in both the healthy and diseased or transplanted liver.


  • 1997–present
    Senior Research Officer, Centenary Institute
  • 1995–1997
    Research Officer, Ecole Normale Superieure de Lyon, France
  • 1992–1995
    Research Officer, The Walter and Eliza Hall Institute of Medical Research


  • 2011
    Hepatocyte entry leads to degradation of autoreactive CD8 T cells. , PNAS
  • 2008
    Intrahepatic murine CD8 T cell activ. associates with a phenotype leading to Bim-dep. death. , Gastroenterology
  • 2007
    The liver ; a special case in transplantation tolerance., Seminars in Liver diseases
  • 2006
    T lymphocytes interact with hepatocytes through fenestrations in murine LSEC. , Hepatology
  • 2005
    Intrahepatic Immunity : a tale of two sites ? , Trends in Immunology
  • 2004
    The site of primary T cell activation is a determinant of the balance between tol. and immunity. , Journal of Clinical Investigation
  • 2002
    Cytokine bystander hepatitis due to intrahepatic murine CD8T cell activation by bm derived cells., Gastroenterology
  • 2001
    Primary activation of CD8+ T cells within the liver. , Journal of Immunology

Grants and Contracts

  • 2011
    Deciphering mechanisms of liver allograft tolerance
    Chief Investigator
    Funding Source:
    Australian Government (NHMRC)
  • 2010
    Inflammation, Angiogenesis and Cancer
    Chief Investigator
    Funding Source:
    Australian government

Research Areas

  • Immunology (1107)
  • Transplantation Immunology (110708)
  • Gastroenterology And Hepatology (110307)