In close collaboration with Dr Brendan McMorran and Dr Gaetan Burgio, our group is interested in the host response to malaria. We are intrigued by the fact that although many (most) children in malarial endemic areas are infected with very similar, if not identical malarial parasites, only a small percentage of children succumb to disease. We are convinced there is substantial difference in the host response to infection and are trying to determine these differences and to exploit them to develop new antimalarial therapies.