Dr. Bain is an Assistant Profess of Medicine in Pulmonary, Allergy and Critical Care Medicine. His research goal is to improve understanding of how the lung interacts with and employs cellular and humoral elements of innate immunity to combat pathogens and manage injury. He is currently focused upon two research questions. First, how do platelets and platelet factors attenuate lung injury during pathogen-mediated lung injury with particular attention to the role of platelet released factors in providing protection to alveolar epithelium? Second, what are mechanisms by which alternative complement pathway function supports host defense and patient survival during critical illness with acute respiratory failure?