Activists, health-care workers and scientists in South Africa were faced with a horrific epidemic but went on a ruthless crusade to turn it around.
Understanding what causes diseases is a life-and-death matter. It is a complicated issue that has generated a great deal of debate in the medical community.
Critics say that Thabo Mbeki's character matters less than his AIDS denialism. But these things are actually intimately linked.
Although men make up two-thirds of HIV-related deaths, there are not enough services geared towards helping them.