Drugs can convert between different isomers in the body, leading to unexpected effects.
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From thalidomide to resveratrol, molecules with the exact same chemical properties can have drastically different effects in the body depending on how they’re arranged in space.
Inflammatory cells surrounding amyloid plaque and activation of astrocytes, critical in maintaining the brain health.
Curtin Health Innovation Research Institute
Not all Alzheimer’s research has been compromised by allegations of scientific fraud. But we should interrogate whether the governing bodies of research and drug approvals are truly effective.
Communities that are underrepresented in research may also be at increased risk for dementia, or tend to experience dementia differently, often with poorer quality of care, later diagnoses and at possibly higher rates than the general population.
Much dementia research does not reflect ethnically diverse communities. Studies used to make policy, clinical and investment decisions in dementia should reflect the diverse Canadian population.
Noradrenergic drugs were shown to improve some brain function and feelings of apathy.
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Noradrenergic drugs are already used to treat a variety of conditions, including ADHD and depression.
Stereotypes and common misconceptions about dementia often emerge in the metaphors used to explain and understand it.
Because they help to create a shared understanding, metaphors can play a critical role in navigating the gap between the knowledge patients and health-care providers bring.
It hasn’t been known until now to what extent your night’s sleep affects short-term dementia symptoms.
Participants who woke up fewer times during the night performed better on memory tasks the next day.
It is possible to grow cells from a skin sample in a Petri dish and transform them into neurons in about a month.
Cell cultures have shown promise in representing diseases. The Petri dish is not as different from a sick person as one might think.
The brain’s neural network, which includes both gray and white matter.
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Long overlooked by scientists, white matter may provide clues to some of the brain’s greatest mysteries.
An illustration of amyloid plaques within the human brain, characteristic features of Alzheimer’s. By 2060, approximately 14 million Americans are expected to have the disease.
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Although Medicare has agreed to pay for Aduhelm, its coverage comes with restrictions.
As the population of American Indian and Alaska Native adults ages, the risk for Alzheimer’s disease and other dementias – along with various chronic conditions – goes up.
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A clearer understanding of the true treatment costs of dementia for American Indian and Alaska Native adults could help health services better meet the needs of the populations they serve.
Older adults who nap at least once for more than an hour a day have a 40% higher chance of developing dementia.
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While longer naps are a normal part of aging, excessively long dozes could be a warning signal for cognitive decline.
The cells which clear Alzheimer’s plaques from the brain follow a 24-hour circadian rhythm.
If replicated in humans, these findings could mean that targeting or boosting the circadian rhythm in Alzheimer’s patients, could help with managing the disease
Conflicts between residents with dementia occur often in long-term care settings.
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Research shows that violence between patients is prevalent, often overlooked and largely unaddressed.
If you’re worried about older loved ones’ ability to care for themselves, try starting a conversation with nonjudgmental questions.
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In tough conversations, show your respect for loved ones’ autonomy and dignity.
The symptoms of menopause, which can include sleep disturbance, depression, anxiety and ‘brain fog’ can span perimenopause and last for up to ten years.
Physical activity can help protect the brain as we age.
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People who were more active had lower levels of inflammation in their brain.
Does too much sleep really increase your risk of cognitive decline?
The researchers found that people who slept less than 4.5 hours and more than 6.5 hours every night had a greater risk of cognitive decline.
Our research suggests the multiplication of protein aggregates in individual regions of the brain, rather than their spread between regions, is key to the progression of Alzheimer’s disease.
PET scans using a special tracer can pick up ‘tau tangles’ in the brain.
Vocabulary surrounding Alzheimer’s and other related disorders must be carefully chosen. Here, sculpture by Jaume Plensa, in Montréal.
Arts-related activities for people living with Alzheimer’s and other related disorders could improve people’s quality of life, but collaborating in communities requires a common language.