Over half of the human genome contains repetitive DNA sequences whose functions are still not fully understood.
Malte Mueller/fStop via Getty Images
Advances in technology have enabled researchers to sequence the large regions of repetitive DNA that eluded the Human Genome Project.
Genetic therapies may treat previously uncurable conditions, like sickle cell disease.
Scientists have been eager to edit genomes to eliminate certain diseases. New WHO reports outlines ethical approaches to research and treatment.
Two decades after the ‘full’ human genetic code was released to global fanfare, researchers have finally filled in the blanks that made up 8% of the sequence, thanks to recent advances in genome sequencing.
A complete human genome, seen here in pairs of chromosomes, offers a wealth of information, but it is hard connect genetics to traits or disease.
The first full human genome was sequenced 20 years ago. Now, a project is underway to sequence 1 million genomes to better understand the complex relationship between genetics, diversity and disease.
The achievement didn’t live up to the hype, but it has illuminated new areas of ‘genetic dark matter’.
A new finding in mice rewrites the textbook explanation of the male sex-determining gene, Sry. It might also help us better understand how males and females come to be.
Early proponents of genome sequencing made misleading predictions about its potential in medicine.
Genome sequencing technologies have transformed biological research in many ways, but have had a much smaller effect on the treatment of common diseases.
Genetic studies need to be more diverse.
Genome-wide association studies are more like genome white association studies.
CRISPR is a gene editing tool that can create permanent changes in the human genome.
Four months ago a researcher claimed he had used the tool CRISPR to edit the genomes of twin girls. Now prominent researchers and ethicists are calling for a temporary halt to this sort of work.
Indigenous Australians must be involved in research around provenance and country. Here, representatives of the Willandra Aboriginal Elders visit the Griffith University ancient DNA laboratory.
Museums around the world hold remains of Aboriginal people that were often taken without permission and in the absence of accurate records. New DNA methods may help return these items to country.
Jiankui He claims he has used CRISPR to edit the genomes of twin girls.
The world seemed to be inching forward with CRISPR gene editing technology – but suddenly the forbidden fruit has been plucked, and some even worry that the CRISPR tree has been cut down.
Academics from different disciplines come Head to Head in this series to tackle topical debates.
We need to know gene editing technology is precise before we try to use it to cure diseases.
A new study found the Cas9 gene editing scissors don’t stop cutting after we tell them to.
You’re knicked - and so is your DNA.
A bit of advice for any criminals inspired to try and edit their own genes – it’s unlikely to work, and it may present health risks.
Families have secrets - and sometimes we don’t know our complete genetic histories.
Ancestry and identity are not the same thing. A scientist tells the story of what happened when he sent his DNA to an ancestry company.
Females who remain unidentified at the time of burial are named ‘Jane Doe’.
We’re at the point in DNA technology where individuals who – having parted with $99 and a small vial of saliva – may suddenly find themselves in a criminal investigation.
When the Human Genome Project completed its work in 2003, the entire human genome was published in book form.
Stephen C. Dickson/Wikimedia
In 2003 the Human Genome Project “cracked the code of life”, yet parts of our DNA remained unidentified. A new study fills out our genetic blueprint by using a nanotechnology-based technique.
From the man who gave away his genome under open consent, to the 'Mathematikado', this episode of the podcast features highlights from the British Science Festival in Brighton.
As genes are favored or phased out, human evolution continues.
Comparing genomes of more than 200,000 people, researchers identified genetic variants that are less common in older people, suggesting natural selection continues to weed out disadvantageous traits.
Professor Samir Brahmachar: ‘Why should drug discovery be kept in the Wright brothers’ era of trial and error?’
Professor Samir Brahmachari’s innovative Open Source Drug Development allows thousands of researchers to work together to discover novel therapies for under-studied diseases.