Articles on Treatment-resistant depression

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The vine Banisteriopsis caapi is one ingredient in ayahuasca, a psychedelic brew that Amazonian indigenous populations have long used for spiritual purposes. Apollo/flickr

Amazonian psychedelic may ease severe depression, new study shows

Ayahuasca has long been used for indigenous healing and spiritual rituals. Now, a Brazilian clinical trial has confirmed that this psychoactive drink can help those with even severe depression.
The experimental technique of ‘deep brain stimulation’ has improved the lives of patients with treatment-resistant depression, despite the ‘failure’ of a large clinical trial. (Shutterstock)

Could an experimental brain surgery make you happier?

For some patients, drilling a hole in the skull and inserting an electrode into the 'sadness centre' of the brain offers relief from debilitating and otherwise treatment-resistant depression.

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