Ruth Itzhaki has spent more than 30 years researching whether certain common viruses play a role in the development of Alzheimer’s. But for years her research was greeted with hostility.
London schoolchildren in 1950.
Trinity Mirror / Mirrorpix / Alamy Stock Photo
Just months after the end of the second world war, the longest running study of health over the human life course in the world began – and it’s still going.
Missing person calls involving an individual with dementia increased by between 10 and 50 per cent across all Ontario regions over the last five years.
(Shutterstock)
With an increasing number of people living with dementia worldwide and in Canada, it’s crucial to find ways to promote community awareness and prevent people with dementia from getting lost.
Uncharted Brain: Decoding Dementia is a new podcast series from The Conversation.
Action is needed to hold off a wave of dementia cases in an aging population. One of the most effective tools to reduce the prevalence of dementia is to address modifiable factors.
A new theory of Alzheimer’s disease reassesses the role of beta-amyloid in the brain.
(AP Photo/Evan Vucci)
Alzheimer’s may not be primarily a disease of the brain. It may be a disorder of the immune system within the brain. Beta-amyloid may not be an abnormal protein, but part of the brain’s immune system.
A thinning of the retina is associated with earlier ageing of the brain. Widely available retinal imaging could help detect cognitive decline in its earliest stages.
Rhesus macaques experience an aging process similar to people’s.
Goddard Photography/E+ via Getty Images
Nonhuman primates like rhesus monkeys share certain characteristics with people that may make them better study subjects than mice for research on neurodegenerative diseases.
From thalidomide to resveratrol, molecules with the exact same chemical properties can have drastically different effects in the body depending on how they’re arranged in space.
Inflammatory cells surrounding amyloid plaque and activation of astrocytes, critical in maintaining the brain health.
Curtin Health Innovation Research Institute
Not all Alzheimer’s research has been compromised by allegations of scientific fraud. But we should interrogate whether the governing bodies of research and drug approvals are truly effective.
Communities that are underrepresented in research may also be at increased risk for dementia, or tend to experience dementia differently, often with poorer quality of care, later diagnoses and at possibly higher rates than the general population.
(Shutterstock)
Much dementia research does not reflect ethnically diverse communities. Studies used to make policy, clinical and investment decisions in dementia should reflect the diverse Canadian population.
Deputy Director, McKnight Brain Institute, Aerts-Cosper Professor of Alzheimer’s Research, and Professor of Neurology and Neuroscience, University of Florida
Director, Evelyn F. and William L. McKnight Brain Institute Director, 1Florida Alzheimer’s Disease Research Center, Professor, Department of Neuroscience, College of Medicine University of Florida, University of Florida